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Will I Need To Use This Drug Long Term? cilostazol Two metabolites are lively, with one metabolite appearing to account for a minimum of 50% of the pharmacologic exercise after administration of cilostazol. HumansAbsorptionCilostazol is absorbed after oral administration. Erythromycin (E.E.S, Erythrocin), omeprazole and diltiazem enhance the concentration of cilostazol by blocking the action of enzymes that destroy cilostazol. Though not particularly studied, an analogous interplay could occur with ketoconazole , itraconazole , fluconazole , miconazole , fluvoxamine , fluoxetine , nefazodone and sertraline . Buy cilostazol 200mg tablets. Due to the way in which this drug works, it will increase the affected person's coronary heart price and may have an effect on the guts rhythm.Other drugs in this identical class have been shown to increase mortality due to these results.Therefore, cilostazol is contraindicated to be used in patients with heart failure.PLETAL has not been studied in sufferers with quickly progressing claudication or in patients with leg pain at relaxation, ischemic leg ulcers, or gangrene.In a pooled evaluation of the six trials, sufferers treated with both PLETAL 100 mg twice day by day or 50 mg twice daily reported enhancements of their walking pace and strolling distance as compared to placebo. No measurable amount of unchanged cilostazol was excreted within the urine, and less than 2% of the dose was excreted as three,four-dehydro-cilostazol. About 30% of the dose was excreted in urine as 4'-trans-hydroxy-cilostazol. Website URL: